Antimicrobial Stewardship Protocols

Clinical Pathways and Guidance

Guidelines for Initial Therapy for Common Pediatrics Infections (PDF)

Acute Leukemia Antimicrobial and Antifungal Prophylaxis Guidelines (PDF)

Antibiotic Prophylaxis in ECMO Patients: Cannulation in Sterile Setting and Cannulation in Non-Sterile Setting

Antibiotic-Loaded Bone Cement

Appendicitis Antibiotic Selection Guideline

Community Acquired Pneumonia

Drug-Susceptible Tuberculosis Therapy Guideline (PDF) and ID Fellow’s TB Guide

ENT and Plastics Peri-Operative Antibiotic Prophylaxis Guidelines

Fever in Infants (8 to 21 days old) Pathway

Fever and Neutropenia Guidelines in Pediatric Oncology

Liver Transplant Post-Op Antimicrobial Selection and Duration

Neonatal and Young Infant (7-60 day) Urinary Tract Infection Pathway

NICU Late Onset Sepsis Algorithm

OB Sepsis Pathway

Pediatric Sepsis and Septic Shock Pathway

Prolonged Fever and Neutropenia Pathway

RSV Infant Prophylaxis: Nirsevimab (Beyfortus®) Guideline

Skin and Soft Tissue Infections 

Surgical Prophylaxis Guidelines:

• LPCH Surgical Prophylaxis Guideline
• ASHP Surgical Prophylaxis Guideline
• Obstetrics: Pre-Incision Antibiotics for Cesarean Delivery Algorithm (PDF) and REDCap Decision Support Tool

Urinary Tract Infections

Antimicrobial Dosing and Monitoring

Antimicrobial Monitoring Guidelines (PDF)

Amoxicillin-clavulanate (Augmentin®) Dosing Guide (PDF)

Azole Antifungal Therapeutic Drug Monitoring Guidance

Housestaff Manual

LPCH Blue Card – Antibiogram and Antimicrobial Dosing Quick Reference Card (PDF)

Pediatric Renal Antibiotic Dosing Recommendations

Prolonged Infusion of Beta-Lactam Guidelines

Vancomycin per Pharmacy

• Vancomycin Guideline for Neonates and Children
• Vancomycin Guideline for Obstetric Patients
• Vancomycin Guideline in Hemodialysis
• Initial Vancomycin Dosing Guideline for Surgical Patients up to 1 Week Post-op
• ASHP Vancomycin Therapeutic Monitoring Guidelines

Antibiotic Allergy

Antibiotic Desensitization Protocol

Antibiotic Graded Challenge Protocol

Allergy Clinical Decision Support Tool

– Antibiotic Allergy Clinical Decision Support Tool 
– Antibiotic Allergy Tool – Rationale Document 
– Antibiotic Allergy Tool Instructions Powerpoint (PPTX)
– Video Tutorial 

Antimicrobial Restrictions

List of restricted antimicrobials at LPCH 

ASP Restricted Antimicrobial Approval Process

RSV Resources

Nirsevimab Monoclonal Antibody Memo

COVID-19 Resources

Vaccination

COVID-19 Vaccine 2024-2025 Memo

Treatment

COVID-19 Inpatient Treatment Algorithm

LPCH Therapies for High-Risk Nonhospitalized Patients with Mild to Moderate COVID-19

Multisystem Inflammatory Syndrome in Children (MIS-C) Pathway